Abstract

Portable high-efficiency particulate air (HEPA) filter units are installed in existing medical facilities to rapidly convert to temporary negative pressure isolation(TNPI) rooms. The variation in the statuses of existing facilities led to unstandardized operational statuses, necessitating the development of standards or guidelines. In this study, we reviewed different guidelines relevant to biological cleanrooms to identify the factors that should be considered in future guideline development. As a result, it was revealed that the particle level within the TNPI room must be first defined, and then detailed ventilation methods, including air exchange rate, differential pressures, and temperature control, should be reviewed considering architectural factors and potential contamination risks.